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oniae CpxR very likely binds to DNA, given its sequence homology to other effector domains that have this function. A multiple sequence alignment of the proteins clearly showed that they…

ing the fact that there was no significant difference in free Heme level between CXC102/2 infected mice and non-infected controls, we postulated that HO-1 activation may not be required under…

mmon feature for both biomacromolecules and small-molecules in nature and in our daily life. Biomacromolecules have the potential to stereoselectively recognize and dispose the ligands. For example, it has been…

rine leiomyoma as well as identify potential therapeutic targets. Because DNA methylation is reversible, epigenetic modifying drugs could be used in the medical management of uterine leiomyoma. Importantly, aberrant DNA…

of different compositions. This method has been previously used to osmotically stress bacteria and to dose microcolonies of bacteria and Candida spp. during rapid drug susceptibility testing. Microcolony-based methods combined…

. Adipocyte Debio 1347 differentiation of 3T3-L1 cells was induced by using standard hormonal cocktail. In brief, at two days post-confluence, cells were treated with a differentiation medium containing DMEM…

pic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci U S A 103: 68896894. 29. Osenkowski P, Li H, Ye W,…

have confirmed that CBFb binds to at least the first 140 amino acids of HIV-1 Vif. Thus, the known proteinbinding domains in Vif, including the EloB/C binding BC-box, the cullin…

oblasts. Resveratrol inhibits nicotinamide-induced downregulation of Sirt-1 during osteogenic differentiation of MSCs in vitro To investigate the possible mechanism for dedifferentiation of MSCs to adipocytes during osteogenesis, we investigated the…

noglobulin secreting cells would result in loss of LEF-1 expression and decreased leukemic cell survival. Agents that induce terminal differentiation of leukemic cells have been utilized therapeutically with the greatest…