Product Name :
ε-Amanitin
Description:
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.
CAS:
21705-02-2
Molecular Weight:
903.96
Formula:
C39H53N9O14S
Chemical Name:
2-[(1R, 4S, 8R, 10S, 13S, 16S, 34S)-34-[(2S)-butan-2-yl]-8, 22-dihydroxy-13-[(2R, 3S)-3-hydroxybutan-2-yl]-2, 5, 11, 14, 27, 30, 33, 36, 39-nonaoxo-27-thia-3, 6, 12, 15, 25, 29, 32, 35, 38-nonaazapentacyclo[14.12.11.0, .0, .0, ]nonatriaconta-18(26), 19(24), 20, 22-tetraen-4-yl]acetic acid
Smiles :
CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CC3C4=CC=C(O)C=C4NC=3S(=O)C[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H]([C@@H](C)[C@H](C)O)C(=O)N2
InChiKey:
OFILNAORONITPV-ZUROAWGWSA-N
InChi :
InChI=1S/C39H53N9O14S/c1-5-16(2)31-36(59)41-12-28(52)42-26-15-63(62)38-22(21-7-6-19(50)8-23(21)45-38)10-24(33(56)40-13-29(53)46-31)43-37(60)32(17(3)18(4)49)47-35(58)27-9-20(51)14-48(27)39(61)25(11-30(54)55)44-34(26)57/h6-8,16-18,20,24-27,31-32,45,49-51H,5,9-15H2,1-4H3,(H,40,56)(H,41,59)(H,42,52)(H,43,60)(H,44,57)(H,46,53)(H,47,58)(H,54,55)/t16-,17-,18-,20+,24-,25-,26-,27-,31-,32-,63?/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{(-)-Epigallocatechin} MedChemExpress|{(-)-Epigallocatechin} MMP|{(-)-Epigallocatechin} Purity & Documentation|{(-)-Epigallocatechin} In Vitro|{(-)-Epigallocatechin} supplier|{(-)-Epigallocatechin} Autophagy}
Shelf Life:
≥360 days if stored properly.{{DSPC} web|{DSPC} Metabolic Enzyme/Protease|{DSPC} Epigenetics|{DSPC} Biological Activity|{DSPC} Formula|{DSPC} custom synthesis}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32362185
Additional information:
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.|Product information|CAS Number: 21705-02-2|Molecular Weight: 903.96|Formula: C39H53N9O14S|Chemical Name: 2-[(1R, 4S, 8R, 10S, 13S, 16S, 34S)-34-[(2S)-butan-2-yl]-8, 22-dihydroxy-13-[(2R, 3S)-3-hydroxybutan-2-yl]-2, 5, 11, 14, 27, 30, 33, 36, 39-nonaoxo-27-thia-3, 6, 12, 15, 25, 29, 32, 35, 38-nonaazapentacyclo[14.12.11.0, .0, .0, ]nonatriaconta-18(26), 19(24), 20, 22-tetraen-4-yl]acetic acid|Smiles: CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CC3C4=CC=C(O)C=C4NC=3S(=O)C[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H]([C@@H](C)[C@H](C)O)C(=O)N2|InChiKey: OFILNAORONITPV-ZUROAWGWSA-N|InChi: InChI=1S/C39H53N9O14S/c1-5-16(2)31-36(59)41-12-28(52)42-26-15-63(62)38-22(21-7-6-19(50)8-23(21)45-38)10-24(33(56)40-13-29(53)46-31)43-37(60)32(17(3)18(4)49)47-35(58)27-9-20(51)14-48(27)39(61)25(11-30(54)55)44-34(26)57/h6-8,16-18,20,24-27,31-32,45,49-51H,5,9-15H2,1-4H3,(H,40,56)(H,41,59)(H,42,52)(H,43,60)(H,44,57)(H,46,53)(H,47,58)(H,54,55)/t16-,17-,18-,20+,24-,25-,26-,27-,31-,32-,63?/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation.|References:|Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1.Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233.Products are for research use only. Not for human use.|