Ient underwent resection of a perforated portion of Adrenomedullin/ADM Protein Gene ID sigmoid colon. Histopathologically
Ient underwent resection of a perforated portion of sigmoid colon. CXCL16 Protein Formulation Histopathologically, sevelamer crystals had been detected at the website of perforation.a r t i c l e i n f oArticle history: Received five May 2016 Received in revised form 24 July 2016 Accepted 24 July 2016 Keywords and phrases: Sevelamer crystal Colon perforation Chronic renal failure Hemodialysisa b s t r a c tIntroduction: Sevelamer is definitely an anion exchange resin used to treat hyperphosphatemia. A frequent adverse effect of sevelamer is constipation. As outlined by a evaluation with the readily available literature, colon perforation related with this resin agent was significantly less typical. Presentation of case: A 66-year-old man complaining of lower abdominal pain was transferred to our hospital. The patient had been undergoing hemodialysis for chronic renal failure on account of rapidly progressive glomerulonephritis, and had been receiving sevelamer hydrochloride 4.five g/day for 8years as therapy for hyperphosphatemia. Abdominal computed tomography revealed ascites, no cost air within the abdominal cavity, various diverticula with the sigmoid colon, too as enhanced fat tissue surrounding the sigmoid colon. We diagnosed colonic perforation and performed emergency surgery, which revealed a 5 sirtuininhibitor5 mm perforation within the sigmoid colon surrounded with soft stool. Histopathologically, sevelamer crystals have been detected in the perforation web-site. Discussion: We theorize that physical stimulation by sevelamer crystals contributed to colon perforation at the already vulnerable diverticulum web-site. Conclusion: When sevelamer is administered to sufferers with hemodialysis, the danger of intestinal perforation really should be thought of. sirtuininhibitor2016 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This is an open access short article below the CC BY-NC-ND license (creativecommons.org/licenses/by-nc-nd/4.0/).1. Introduction Sevelamer is definitely an anion exchange resin utilised to treat hyperphosphatemia in individuals with chronic renal illness [1,2]. It was first approved by the United states of america Meals and Drug Administration in October 1998 as sevelamer hydrochloride (Renagelsirtuininhibitor, and more recently as sevelamer carbonate (Renvelasirtuininhibitor. Sevelamer is calcium cost-free, and for that reason doesn’t lead to the hypercalcemia and vascular calcification linked to calcium-based agents [3e5]. Thisadvantage has contributed for the elevated use of sevelamer. The most normally reported adverse effects of sevelamer are gastrointestinal events such as abdominal bloating, diarrhea, constipation and intestinal obstruction [6e9]. Although issues exist that sevelamer could boost the threat of intestinal perforation, there is certainly small written inside the literature on this topic. Here we describe a case of sigmoid colon perforation for the duration of remedy with sevelamer hydrochloride. Histopathologically, sevelamer crystals were detected in the site of perforated sigmoid colon. Corresponding author. E-mail address: takahisa.1003@gmail (T. Yamaguchi). dx.doi.org/10.1016/j.amsu.2016.07.020 2049-0801/sirtuininhibitor2016 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This can be an open access article below the CC BY-NC-ND license ( creativecommons.org/licenses/by-nc-nd/4.0/).T. Yamaguchi et al. / Annals of Medicine and Surgery ten (2016) 57e2. Presentation of case A 66-year-old man complaining of serious reduced abdominal discomfort was transferred to our hospital in July 2014. His health-related history was considerable for left.
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