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Human exposure to Ni in occupational settings is linked using a number of pathological effects such as skin allergies, lung fibrosis, and cancer in the respiratory tract [1,2]. Quite a few NiPLOS One | DOI:10.1371/journal.pone.0159684 July 19,1 /Nickel Release, ROS Generation and Toxicity of Ni and NiO Micro- and Nanoparticlescompounds which include high temperature green Ni oxide are classified as “human carcinogen by means of inhalation exposure” (Group 1Ai) [3], whereas Ni metal particles are classified as “possibly carcinogenic” (Group 2B) [4]. Pulmonary exposure to Ni-containing dusts and fumes is mostly prevalent in metal refining and processing industries. Having said that, the expanding production of Ni-containing nanomaterial presents an emerging concern [5]. In spite of quite a few research around the toxicity of Ni, there’s a lack of understanding each on the characteristics and the effects of nano-sized Ni-containing particles. Evidently, the capability of Ni-containing particles to release Ni is often a critical parameter from the risk assessment viewpoint. Skin irritation induced by Ni, one example is, seems to be solely.