D B cells exhibit substantially longer telomeres and increased telomerase activity (12). The present study

D B cells exhibit substantially longer telomeres and increased telomerase activity (12). The present study aimed to investigate the cytotoxic mechanisms of CAUE in NALM-6 cells and, as shown in Fig. 1, CAUE exhibited preferential Nav1.8 Inhibitor Compound damage to DNA synthesis compared with RNA and protein synthesis. This indicated that CAUE straight affects the nucleus and impairs DNA synthesis, resulting within the induction of apoptosis. Caffeic acid phenethyl ester is actually a parent compound of CAUE and one of its pharmacological mechanisms of DNA harm includes the PAK4 Inhibitor Accession inhibition of nuclear issue B (NF- B) (13). Caffeic acid derivatives block NF- B activation (7), and it has been hypothesized that NF- B inhibitory molecules are clinically effective as single therapeutic agents or in combination with classical chemotherapeutic agents for the remedy of hematological malignancies (14). For that reason, CAUE may well inhibit NF- B in leukemia cells and damage DNA to trigger the induction of apoptosis. NF- B regulates hTERT expression by binding to a internet site 350-bp upstream on the translational initiation web page (15). Also, it has been reported that telomerase directly regulates NF- B-dependent genes in cancer cells (16). As a result, there is a close correlation amongst NF- B and telomerase activity. The results from the present study indicate that CAUE inhibits telomerase activation by means of mediation of hTERT protein expression, hence, we hypothesize that the inhibition by CAUE is dependent on the inhibition of NF- B activation.In conclusion, CAUE inhibits DNA synthesis and suppresses telomerase activity. Targeting the inhibition of telomerase has been hypothesized to become effective for cancer chemotherapy because of its selectivity against malignant cells, thereby decreasing side-effects. Telomerase inhibition is probably to be tested on humans inside the future, in an effort to treat lymphoid cancers, including B-cell leukemia (17). The observations in the present study could therefore help the improvement of therapeutic approaches for leukemia sufferers.
Open Access Case ReportLaparoscopic removal of an intrauterine device from the sigmoid colonFatih anlikan1, Ouz Arslan2, Muhittin Eftal Avci3, Ahmet G men4 ABSTRACT Uterine wall perforation which can be commonly observed through the posterior wall from the uterus would be the most seriouscomplicationofanintrauterinedevice(IUD).WepresentacaseoflaparoscopicremovalofanIUD fromthesigmoidcolonina31-years-oldfemalewhowasadmittedtohospitalwithahistoryofpelvicpain andabnormalvaginalbleedingforonemonth.ThedislocatedIUDwasremovedfromthesigmoidcolonof laparoscopicinterventionwithoutanycomplications. In conclusion, the treatment modality for the removal of a dislocated IUD is attainable by laparoscopic surgeryinselectedpatientswherethedislocatedIUDisaccessible. Important WORDS: Dislocatedintrauterinedevice,Laparoscopicsurgery.doi: dx.doi.org/10.12669/pjms.311.How you can cite this:anlikan F, Arslan O, Avci ME, G males A. Laparoscopic removal of an intrauterine device in the sigmoid colon. Pak J Med Sci 2015;31(1):214-216. doi: dx.doi.org/10.12669/pjms.311.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(creativecommons.org/licenses/by/3.0), whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.INTRODUCTION The usage of an intrauterine device as a contraceptive method is extremely typical within the planet, in particular in creating countries. In Turkey, where the fertility rates are slightly greater than the world.