to date to greater inform choice creating and patient blood management within the antenatal care of Bombay sufferers. Outcomes: Haematinics had been optimised to ensure an optimise haemoglobin. Anti-H titres were tracked all through pregnancy and have been 1:256 at both 28 weeks and 36 weeks gestation. Standard middle cerebral artery dopplers have been performed to assess for fetal anaemia. There was continuous communication with obstetrics and D5 Receptor Agonist web anaesthetics throughout the antenatal period. Both autologous frozen and straight donated fresh red cells had been obtainable as part of a clear detailed transfusion strategy for the patient (Figure 1). Transfusion was not necessary and neither youngster was impacted by haemolytic illness of your foetus and newborn. The neonates have been blood group O, DAT negative, and blood group A, DAT good. Maternal anti-A was detected within the neonatal eluate.PB1316|Bombay Phenotype and Twin Pregnancy: Case Report and Literature Critique M. Krigstein; N. Cromer Royal North Shore Hospital, St Leonards, Australia Background: Bombay phenotype is uncommon and case reports of antenatal care in these patients are scarce. We present an even rarer case of a Bombay female pregnant with twins and detail her multidisciplinary management and outcome. Aims: In conjunction having a literature review of all published situations, we hope this assists other clinicians with their decision producing inside the antenatal management of this uniquely challenging scenario. Conclusions: Bombay phenotype poses unique challenges for the duration of pregnancy, especially when postpartum haemorrhage danger is improved for instance twin pregnancy. Via employing patient blood management methods, engaging a collaborative multidisciplinary method involving anaesthetics and high danger obstetrics, along with a clear detailed delivery strategy, these challenges might be surmounted. FIGURE 1 Detailed Haemostasis / Transfusion Program for our twin delivery with Bombay blood groupABSTRACT971 of|PO190|Profitable Infertility Treatment and Pregnancy Outcome inside a Woman with Extreme Treatment-refractory ITP B. Krastev; P. Arabadjikova; I. Sarbianova; G. Grigorov; M. Eneva; G. Stamenov MHAT Hospital for Girls Wellness Nadezhda, Sofia, BulgariaConclusions: Pregnancy should really not be discouraged in girls with refractory ITP. High-dose IVIG could rescue delivery and mitigate postpartum maternal bleeding but neonates are nonetheless at threat of severe thrombocytopenia.PO191|The Case of Obstetric APS – A Therapeutic Challenge Background: A proportion of sufferers with idiopathic thrombocytopenic purpura (ITP) are refractory to remedy and in young ladies this poses risk to pregnancy and delivery. Aims: Procedures: Results: J. Teliga-Czajkowska1; K. Czajkowski2; A. SikorskaMedical University of Warsaw, Department of Obstetrics andGynecology Didactics, Warsaw, Poland; 2Medical University of Warsaw; 2nd Division and Clinic of Obstetrics and Gynecology,, Warsaw, Poland; 3Institute of Hematology and Transfusion Medicine, Department of Problems of Hemostasis and Internal Medicine,, Warsaw, Poland Background: Antiphospholipid syndrome – APS – is actually a systemic autoimmune disorder characterized by thrombotic venous or arterial circulation within the presence of antiphospholipid antibodies -aPL: lupus anticoagulant -LA, anticardiolipin antibodies, and antibeta2glycoprotein-I antibodies – IDO1 Inhibitor Biological Activity anti-beta GPI. APS is usually either principal or secondary when it happens within the presence of an underlying autoimmune disorder. Pathophysiologic mechanism underlying thrombosis and pregnancy
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