symptoms, and reduced CK blood levels. A randomized, placebo-controlled, double-blind trial was performed on 15

symptoms, and reduced CK blood levels. A randomized, placebo-controlled, double-blind trial was performed on 15 subjects, randomly assigned to the Cureitor placebo group. They underwent 4 days of intervention, in the course of which they ingested a single oral dose of 500 mg of Cureitor placebo right after a 45 min eccentric muscle injury test running downhill on a treadmill. Evidence showed a considerable improvement right after Cureittreatment against DOMS in addition to a optimistic effect on muscle recovery [100]. Liposomes are aspect of a phospholipid-based vesicular technique, among IL-1 Antagonist Accession probably the most extensively investigated lipid drug carriers. Their good results is resulting from their amphiphilic nature, higher biocompatibility, and high affinity for biological membranes, given that they can be swiftly taken up by way of pinocytosis or facilitated diffusion across lipophilic cell membranes [56,60]. Meriva[101] can be a curcumin hosphatidylcholine complicated derived from soy lecithin,Pharmaceutics 2021, 13,11 ofmicrocrystalline cellulose and 180 curcuminoids [56]. When nine volunteers, supplemented with a low or high dosage (209 mg and 376 mg of total curcuminoids, respectively) of Meriva, as well as unformulated curcumin (1799 mg total curcuminoids), Cereblon Inhibitor list within a single oral administration, had been randomly assigned a single therapy for each and every 7-day washout period, free of charge curcumin was not observed in any plasma samples but total curcumin appeared to be 18-fold greater in Merivacompared for the corresponding unformulated powder [60]. The administration of Meriva(500 mg/die, 4-month therapy) in association with glucosamine (500 mg) was found to alleviate the symptoms and reduce the need to have for additional medicines in sufferers impacted by knee OA (n = 63) compared to the administration of chondroitin sulphate + glucosamine (400 mg + 415 mg; n = 61) [102]. Similarly, the administration of Algocur(containing 1 g of Meriva) twice every day for five or 10 days drastically enhanced impaired physical function of male rugby players impacted by osteo-muscular discomfort triggered by traumatic injuries (n = 25). The impact was superimposable to standard anti-inflammatory therapy (n = 25), but within the Merivagroup, the adherence to therapy was greater because of the absence of adverse events [103]. The daily assumption of 500 mg of Merivawas also tested on visual acuity and optical coherence tomography (OCT) retinal thickness in individuals with chronic diabetic macular edema. For the duration of a 3-month open-label study of 12 eyes, 92 showed a reduction of macula edema, 8 showed stabilization, and 0 showed a clinically meaningful boost [104]. Finally, a prospective phase II, singlecenter, single arm trial was carried out to investigate the efficacy and security of curcumin as a complementary therapy to gemcitabine in sophisticated pancreatic cancer individuals (n = 44). Meriva(2000 mg/day) was administered orally though gemcitabine was infused on days 1, eight, and 15 within a 28-day therapy cycle. Overall cycles were nine and Merivawas continued after therapy completion (up to 42 months). Final results suggested preliminary evidence in the effectiveness on the co-treatment with Merivaand gemcitabine that could possibly be compared to the combination of paclitaxel and gemcitabine with all the advantage of creating less toxicity [105] (Table 2). As opposed to liposomes, strong lipid (nano)-particles (SLPs) are only appropriate for hydrophobic drugs. They share with liposomes higher biocompatibility, enhanced bioavailability, and higher drug loading, but SLPs seem to become additional stable and less complicated to manufactu