FC 131

Description:
FC 131 is a cyclic peptide with potent chemoattractant properties. It has been shown to cause cell lysis in HL-60 cells, which is a type of white blood cell. FC 131 also inhibits the binding of CXCR4 ligands to their receptor and blocks migration of hematopoietic cells. These effects have been shown to be dose-dependent and time-dependent, as well as reversible in some cases. This chemokine has been shown to be clinically relevant for the treatment of autoimmune and inflammatory diseases, cancer, HIV infection, and other conditions where chemotaxis plays an important role. The potential therapeutic use of FC 131 is limited by its short half life in vivo.