Product Name :
Luteolin
Description:
Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance. Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Luteolin possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions.
CAS:
491-70-3
Molecular Weight:
286.24
Formula:
C15H10O6
Chemical Name:
2-(3, 4-Dihydroxyphenyl)-5, 7-dihydroxy-4-benzopyrone
Smiles :
OC1=CC=C(C=C1O)C1=CC(=O)C2=C(C=C(O)C=C2O)O1
InChiKey:
IQPNAANSBPBGFQ-UHFFFAOYSA-N
InChi :
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Luteolin is a flavone, a type of flavonoid.{{DREADD agonist 21} web|{DREADD agonist 21} Agonist|{DREADD agonist 21} Immunology/Inflammation|{DREADD agonist 21} Technical Information|{DREADD agonist 21} In Vitro|{DREADD agonist 21} custom synthesis} Like all flavonoids, it has a yellow crystalline appearance.{{Neuromedin B} medchemexpress|{Neuromedin B} Endogenous Metabolite|{Neuromedin B} Technical Information|{Neuromedin B} In Vitro|{Neuromedin B} supplier|{Neuromedin B} Autophagy} Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Luteolin possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions.PMID:23724934 |Product information|CAS Number: 491-70-3|Molecular Weight: 286.24|Formula: C15H10O6|Synonym:|BRN 0292084|C.I. 75590|C.I. Natural Yellow 2|CCRIS 3790|Cyanidenon 1470|Digitoflavone|Flacitran|Luteoline|Luteolol|Salifazide|Luteolin|Chemical Name: 2-(3, 4-Dihydroxyphenyl)-5, 7-dihydroxy-4-benzopyrone|Smiles: OC1=CC=C(C=C1O)C1=CC(=O)C2=C(C=C(O)C=C2O)O1|InChiKey: IQPNAANSBPBGFQ-UHFFFAOYSA-N|InChi: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 57 mg/mL (199.13 mM) Ethanol (warmed with 50ºC water bath) 3 mg/mL (10.48 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha.|In Vivo:|LD50: Mice >2500mg/kg (i.g.)|References:|Xagorari A, et al. J Pharmacol Exp Ther, 2001, 296(1), 181-187.Yu MC, et al. Eur J Pharmacol, 2010, 627(1-3), 269-275.Products are for research use only. Not for human use.|