Product Name :
3, 3′-Difluorobenzaldazine
Description:
3,3′-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3′-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range.
CAS:
15332-10-2
Molecular Weight:
244.24
Formula:
C14H10F2N2
Chemical Name:
(E,E)-bis[(3-fluorophenyl)methylidene]hydrazine
Smiles :
FC1=CC(/C=N/N=C/C2C=C(F)C=CC=2)=CC=C1
InChiKey:
YYMCVDNIIFNDJK-BEQMOXJMSA-N
InChi :
InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Zilovertamab vedotin} web|{Zilovertamab vedotin} Antibody-drug Conjugate/ADC Related|{Zilovertamab vedotin} Protocol|{Zilovertamab vedotin} References|{Zilovertamab vedotin} supplier|{Zilovertamab vedotin} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
3,3′-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3′-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range.|Product information|CAS Number: 15332-10-2|Molecular Weight: 244.24|Formula: C14H10F2N2|Chemical Name: (E,E)-bis[(3-fluorophenyl)methylidene]hydrazine|Smiles: FC1=CC(/C=N/N=C/C2C=C(F)C=CC=2)=CC=C1|InChiKey: YYMCVDNIIFNDJK-BEQMOXJMSA-N|InChi: InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lovastatin} medchemexpress|{Lovastatin} HMG-CoA Reductase (HMGCR)|{Lovastatin} Purity & Documentation|{Lovastatin} Data Sheet|{Lovastatin} supplier|{Lovastatin} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24268253 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|3,3′-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3′-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies.|In Vivo:|3,3′-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.|Products are for research use only. Not for human use.|