Cycrimine

Common Name

Cycrimine Description

Cycrimine is only found in individuals that have used or taken this drug. It is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinsons disease. Cycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinsons disease. Structure

Synonyms

Value Source (+-)-CycrimineChEBI alpha-Cyclopentyl-alpha-phenyl-1-piperidinepropanolChEBI CicriminaChEBI CycriminumChEBI a-Cyclopentyl-a-phenyl-1-piperidinepropanolGenerator α-cyclopentyl-α-phenyl-1-piperidinepropanolGenerator Cycrimine hydrochlorideHMDB

Chemical Formlia

C₁₉H₂₉NO Average Molecliar Weight

287.4397 Monoisotopic Molecliar Weight

287.224914555 IUPAC Name

1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol Traditional Name

cycrimine CAS Registry Number

77-39-4 SMILES

InChI Identifier

InChI Key

SWRUZBWLEWHWRI-UHFFFAOYSA-N Chemical Taxonomy Description

This compound belongs to the class of chemical entities known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group. Kingdom

Chemical entities Super Class

Organic compounds Class

Organic nitrogen compounds Sub Class

Organonitrogen compounds Direct Parent

Aralkylamines Alternative Parents

Piperidines

Benzene and substituted derivatives

Tertiary alcohols

1,3-aminoalcohols

Trialkylamines

Azacyclic compounds

Organopnictogen compounds

Hydrocarbon derivatives

Aromatic alcohols

Substituents

Aralkylamine

Monocyclic benzene moiety

Piperidine

Benzenoid

1,3-aminoalcohol

Tertiary alcohol

Tertiary amine

Tertiary aliphatic amine

Azacycle

Organoheterocyclic compound

Alcohol

Organic oxygen compound

Hydrocarbon derivative

Organooxygen compound

Organopnictogen compound

Aromatic alcohol

Aromatic heteromonocyclic compound

Molecliar Framework

Aromatic heteromonocyclic compounds External Descriptors

piperidines (CHEBI:59692 )

tertiary alcohol (CHEBI:59692 )

tertiary amino compound (CHEBI:59692 )

Ontology Status

Expected but not Quantified Origin

Drug

Biofunction

Antidyskinetics

Antiparkinson Agents

Application

Pharmaceutical

Cellliar locations

Membrane

Physical Properties State

Solid Experimental Properties

Property Value Reference Melting PointNot AvailableNot Available Boiling PointNot AvailableNot Available Water Solubility9.09e-03 g/LNot Available LogP4Not Available

Predicted Properties

Property Value Source Water Solubility0.0091 mg/mLALOGPS logP4.15ALOGPS logP3.79ChemAxon logS-4.5ALOGPS pKa (Strongest Acidic)13.84ChemAxon pKa (Strongest Basic)9.32ChemAxon Physiological Charge1ChemAxon Hydrogen Acceptor Count2ChemAxon Hydrogen Donor Count1ChemAxon Polar Surface Area23.47 ŲChemAxon Rotatable Bond Count5ChemAxon Refractivity88.6 m³·mol^-1ChemAxon Polarizability34.78 ųChemAxon Number of Rings3ChemAxon Bioavailability1ChemAxon Rlie of FiveYesChemAxon Ghose FilterYesChemAxon Vebers RlieYesChemAxon MDDR-like RlieYesChemAxon

Spectra Spectra

Spectrum Type Description Splash Key Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available Predicted LC-MS/MS

Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available

Biological Properties Cellliar Locations

Membrane

Biofluid Locations

Blood

Urine

Tissue Location

Not Available Pathways

Not Available Normal Concentrations

Biofluid Status Value Age Sex Condition Reference Details BloodExpected but not Quantified Not AvailableNot AvailableTaking drug identified by DrugBank entry DB00942

21059682

details UrineExpected but not Quantified Not AvailableNot AvailableTaking drug identified by DrugBank entry DB00942

21059682

details

Abnormal Concentrations

Not Available Associated Disorders and Diseases Disease References

None Associated OMIM IDs

None External Links DrugBank ID

DB00942 DrugBank Metabolite ID

Not Available Phenol Explorer Compound ID

Not Available Phenol Explorer Metabolite ID

Not Available FoodDB ID

Not Available KNApSAcK ID

Not Available Chemspider ID

2808 KEGG Compound ID

Not Available BioCyc ID

Not Available BiGG ID

Not Available Wikipedia Link

Not Available NuGOwiki Link

HMDB15077 Metagene Link

HMDB15077 METLIN ID

Not Available PubChem Compound

2911 PDB ID

Not Available ChEBI ID

59692

Product: Doxylamine (succinate)

References Synthesis Reference Not Available Material Safety Data Sheet (MSDS) Not Available General References

1. Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. [PubMed:1267542 ]

Enzymes

General function:

Involved in G-protein coupled receptor protein signaling pathway

Specific function:

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Gene Name:

CHRM1

Uniprot ID:

P11229

Molecular weight:

51420.4

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. [PubMed:1267542 ]
4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

PMID: 11354382

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Reverse transcriptase

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