Thiophene
Thiophene is a maillard product At room temperature, thiophene is a colorless liquid with a mildly pleasant odor reminiscent of benzene, with which thiophene shares some similarities. The high reactivity of thiophene toward slifonation is the basis for the separation of thiophene from benzene, which are difficlit to separate by distillation due to their similar boiling points (4 C difference at ambient pressure). Like benzene, thiophene forms an azeotrope with water. Not only is thiophene reactive toward electrophiles, it is also readily lithiated with butyl lithium to give 2-lithiothiophene, which is a precursor to a variety of derivatives, including dithienyl.Thiophene has been shown to exhibit antibiotic, anti-microbial, anti-inflammatory and anti-cancer functions (PMID 21443219 , 17070919 , 15358292 , 10462535 ).Thiophene belongs to the family of Thiophenes. These are compounds containing a five-member aromatic compound made up of one slifur atom and four carbon atoms.
Structure for HMDB29718 (Thiophene)
C4H4S
84.14
84.003370818
thiophene
thiophene
110-02-1
YTPLMLYBLZKORZ-UHFFFAOYSA-N
This compound belongs to the class of organic compounds known as heteroaromatic compounds. These are compounds containing an aromatic ring where a carbon atom is linked to an hetero atom.
Organic compounds
Organoheterocyclic compounds
Heteroaromatic compounds
Not Available
Heteroaromatic compounds
Aromatic heteromonocyclic compounds
Detected and Quantified
Not Available
Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available
1H NMR SpectrumNot Available
13C NMR SpectrumNot Available
Not Available
Not Available
Normal
Treated celiac disease
None
None
Not Available
Not Available
Not Available
Not Available
FDB000912
Not Available
7739
C02595
Not Available
Not Available
Thiophene
HMDB29718
HMDB29718
Not Available
8030
Not Available
30856
- Wiles JA, Phadke AS, Bradbury BJ, Pucci MJ, Thanassi JA, Deshpande M: Selenophene-containing inhibitors of type IIA bacterial topoisomerases. J Med Chem. 2011 May 12;54(9):3418-25. doi: 10.1021/jm2002124. Epub 2011 Apr 13. [PubMed:21443219 ]
- Rodriguez-Arguelles MC, Mosquera-Vazquez S, Touron-Touceda P, Sanmartin-Matalobos J, Garcia-Deibe AM, Belicchi-Ferrari M, Pelosi G, Pelizzi C, Zani F: Complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity. J Inorg Biochem. 2007 Jan;101(1):138-47. Epub 2006 Sep 19. [PubMed:17070919 ]
- Pillai AD, Rathod PD, Xavier FP, Vasu KK, Padh H, Sudarsanam V: Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore. Bioorg Med Chem. 2004 Sep 1;12(17):4667-71. [PubMed:15358292 ]
- Nieves-Neira W, Rivera MI, Kohlhagen G, Hursey ML, Pourquier P, Sausville EA, Pommier Y: DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56(3):478-84. [PubMed:10462535 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .