| Common Name |
Methionyl-Phenylalanine
| Description |
Methionyl-Phenylalanine is a dipeptide composed of methionine and phenylalanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28980 (Methionyl-Phenylalanine)
| Synonyms |
| Value |
Source |
L-Methionyl-L-phenylalanineHMDB
m-F DipeptideHMDB
Met-pheHMDB
Methionine phenylalanine dipeptideHMDB
Methionine-phenylalanine dipeptideHMDB
MethionylphenylalanineHMDB
MF DipeptideHMDB
| Chemical Formlia |
C14H20N2O3S
| Average Molecliar Weight |
296.385
| Monoisotopic Molecliar Weight |
296.119463206
| IUPAC Name |
2-[2-amino-4-(methylslifanyl)butanamido]-3-phenylpropanoic acid
| Traditional Name |
2-[2-amino-4-(methylslifanyl)butanamido]-3-phenylpropanoic acid
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(N)C(=O)NC(CC1=CC=CC=C1)C(O)=O
| InChI Identifier |
InChI=1S/C14H20N2O3S/c1-20-8-7-11(15)13(17)16-12(14(18)19)9-10-5-3-2-4-6-10/h2-6,11-12H,7-9,15H2,1H3,(H,16,17)(H,18,19)
| InChI Key |
HGCNKOLVKRAVHD-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Phenylalanine and derivatives
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Phenylpropanoic acids
Amphetamines and derivatives
N-acyl amines
Secondary carboxylic acid amides
Amino acids
Slifenyl compounds
Carboxylic acids
Dialkylthioethers
Monocarboxylic acids and derivatives
Organopnictogen compounds
Organic oxides
Hydrocarbon derivatives
Carbonyl compounds
Monoalkylamines
| Substituents |
Alpha-dipeptide
Phenylalanine or derivatives
Methionine or derivatives
N-acyl-alpha amino acid or derivatives
N-acyl-alpha-amino acid
Alpha-amino acid amide
3-phenylpropanoic-acid
Alpha-amino acid or derivatives
Amphetamine or derivatives
Fatty acyl
Benzenoid
Fatty amide
N-acyl-amine
Monocyclic benzene moiety
Carboxamide group
Secondary carboxylic acid amide
Amino acid or derivatives
Amino acid
Dialkylthioether
Carboxylic acid
Slifenyl compound
Monocarboxylic acid or derivatives
Thioether
Organopnictogen compound
Primary aliphatic amine
Amine
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Primary amine
Organoslifur compound
Organonitrogen compound
Organooxygen compound
Aromatic homomonocyclic compound
| Molecliar Framework |
Aromatic homomonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-1.07Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility0.33 mg/mLALOGPS
logP0ALOGPS
logP-1.1ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)3.83ChemAxon
pKa (Strongest Basic)8.42ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.42 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity79.5 m3·mol-1ChemAxon
Polarizability31.86 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28980
| Metagene Link |
HMDB28980
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: 6″-O-Apiosyl-5-O-Methylvisammioside
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Nelson RD, McCormack RT, Fiegel VD, Simmons RL: Chemotactic deactivation of human neutrophils: evidence for nonspecific and specific components. Infect Immun. 1978 Nov;22(2):441-4. [PubMed:730365 ]
- Koomey M, Bergstrom S, Blake M, Swanson J: Pilin expression and processing in pilus mutants of Neisseria gonorrhoeae: critical role of Gly-1 in assembly. Mol Microbiol. 1991 Feb;5(2):279-87. [PubMed:1674976 ]
- Becker EL, Talley V, Showell HJ, Naccache PH, Shaafi RI: Activation of the rabbit polymorphonuclear leukocyte membrane “Na+, K+”-ATPase by chemotactic factor. J Cell Biol. 1978 May;77(2):329-33. [PubMed:148465 ]
- Matasova NB, Veniaminova AG, Bratskikh LV, Repkova MN, Iamkovoi VI, Karpova GG: [Interaction of mRNA analogs–oligoribonucleotides AUGU3, AUGU6 and (pU)6 with 80S ribosomes from human placenta in the presence of related tRNA and a protein-synthesizing system]. Mol Biol (Mosk). 1993 Mar-Apr;27(2):342-7. [PubMed:8487766 ]
- Matasova NB, Vladimirov SM, Bulygin KN, Veniaminova AG, Bratskikh LV, Mundus DA, Repkova MN, Iamkovoi VI, Karpova GG: [Structural elements of 80S ribosomes located near the 5-region of the mRNA-binding center]. Mol Biol (Mosk). 1994 Jul-Aug;28(4):918-25. [PubMed:7990820 ]
|
PMID: 8298808