| Common Name |
Methionyl-Methionine
| Description |
Methionyl-Methionine is a dipeptied compoosed of two methionine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28979 (Methionyl-Methionine)
| Synonyms |
| Value |
Source |
L-Methionyl-L-methionineHMDB
m-m DipeptideHMDB
Met-metHMDB
Methionine methionine dipeptideHMDB
Methionine-methionine dipeptideHMDB
MethionylmethionineHMDB
MM DipeptideHMDB
Methionylmethionine, (L-met-L-met)-isomerMeSH
DL-MethionylmethionineMeSH
| Chemical Formlia |
C10H20N2O3S2
| Average Molecliar Weight |
280.407
| Monoisotopic Molecliar Weight |
280.091533896
| IUPAC Name |
2-[2-amino-4-(methylslifanyl)butanamido]-4-(methylslifanyl)butanoic acid
| Traditional Name |
2-[2-amino-4-(methylslifanyl)butanamido]-4-(methylslifanyl)butanoic acid
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(N)C(=O)NC(CCSC)C(O)=O
| InChI Identifier |
InChI=1S/C10H20N2O3S2/c1-16-5-3-7(11)9(13)12-8(10(14)15)4-6-17-2/h7-8H,3-6,11H2,1-2H3,(H,12,13)(H,14,15)
| InChI Key |
ZYTPOUNUXRBYGW-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Thia fatty acids
N-acyl amines
Secondary carboxylic acid amides
Amino acids
Slifenyl compounds
Carboxylic acids
Dialkylthioethers
Monocarboxylic acids and derivatives
Carbonyl compounds
Hydrocarbon derivatives
Organic oxides
Monoalkylamines
Organopnictogen compounds
| Substituents |
Alpha-dipeptide
Methionine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Thia fatty acid
Fatty amide
N-acyl-amine
Fatty acid
Fatty acyl
Amino acid
Secondary carboxylic acid amide
Amino acid or derivatives
Carboxamide group
Slifenyl compound
Thioether
Dialkylthioether
Carboxylic acid
Monocarboxylic acid or derivatives
Hydrocarbon derivative
Organopnictogen compound
Organic nitrogen compound
Organic oxide
Primary aliphatic amine
Organonitrogen compound
Organooxygen compound
Carbonyl group
Organoslifur compound
Primary amine
Organic oxygen compound
Amine
Aliphatic acyclic compound
| Molecliar Framework |
Aliphatic acyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-2.08Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility3.03 mg/mLALOGPS
logP-0.42ALOGPS
logP-2.1ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)3.86ChemAxon
pKa (Strongest Basic)8.42ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.42 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity71.97 m3·mol-1ChemAxon
Polarizability29.94 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28979
| Metagene Link |
HMDB28979
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: Imipramine (hydrochloride)
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Alfimova MV, Korovaitseva GI, Lezheiko TV, Golimbet VE: Effect of BDNF Val66Met polymorphism on normal variability of executive functions. Bull Exp Biol Med. 2012 Mar;152(5):606-9. [PubMed:22803145 ]
- Hug GL, Bobrowski K, Kozubek H, Marciniak B: Photo-oxidation of methionine-containing peptides by the 4-carboxybenzophenone triplet state in aqueous solution. Competition between intramolecular two-centered three-electron bonded (S…S)+ and (S…N)+ formation. Photochem Photobiol. 2000 Jul;72(1):1-9. [PubMed:10911722 ]
- Baker DH, Bafundo KW, Boebel KP, Czarnecki GL, Halpin KM: Methionine peptides as potential food supplements: efficacy and susceptibility to Maillard browning. J Nutr. 1984 Feb;114(2):292-7. [PubMed:6693991 ]
- Marco-Pallares J, Nager W, Kramer UM, Cunillera T, Camara E, Cucurell D, Schule R, Schols L, Rodriguez-Fornells A, Munte TF: Neurophysiological markers of novelty processing are modulated by COMT and DRD4 genotypes. Neuroimage. 2010 Nov 15;53(3):962-9. doi: 10.1016/j.neuroimage.2010.02.012. Epub 2010 Feb 12. [PubMed:20156565 ]
- Friedman M, Gumbmann MR: Nutritional value and safety of methionine derivatives, isomeric dipeptides and hydroxy analogs in mice. J Nutr. 1988 Mar;118(3):388-97. [PubMed:3351635 ]
- Boebel KP, Baker DH: Efficacy of methionine peptides as determined by chick bioassay. J Nutr. 1982 Jun;112(6):1130-2. [PubMed:7086542 ]
|
PMID: 7851485