| Common Name |
Methionyl-Lysine
| Description |
Methionyl-Lysine is a dipeptide composed of methionine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28978 (Methionyl-Lysine)
| Synonyms |
| Value |
Source |
L-Methionyl-L-lysineHMDB
m-K DipeptideHMDB
Met-lysHMDB
Methionine lysine dipeptideHMDB
Methionine-lysine dipeptideHMDB
MethionyllysineHMDB
MK DipeptideHMDB
| Chemical Formlia |
C11H23N3O3S
| Average Molecliar Weight |
277.384
| Monoisotopic Molecliar Weight |
277.146012307
| IUPAC Name |
6-amino-2-[2-amino-4-(methylslifanyl)butanamido]hexanoic acid
| Traditional Name |
6-amino-2-[2-amino-4-(methylslifanyl)butanamido]hexanoic acid
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(N)C(=O)NC(CCCCN)C(O)=O
| InChI Identifier |
InChI=1S/C11H23N3O3S/c1-18-7-5-8(13)10(15)14-9(11(16)17)4-2-3-6-12/h8-9H,2-7,12-13H2,1H3,(H,14,15)(H,16,17)
| InChI Key |
IMTUWVJPCQPJEE-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Medium-chain fatty acids
Amino fatty acids
N-acyl amines
Amino acids
Secondary carboxylic acid amides
Monocarboxylic acids and derivatives
Slifenyl compounds
Dialkylthioethers
Carboxylic acids
Organopnictogen compounds
Organic oxides
Monoalkylamines
Hydrocarbon derivatives
Carbonyl compounds
| Substituents |
Alpha-dipeptide
Methionine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Medium-chain fatty acid
Amino fatty acid
Fatty acyl
Fatty acid
Fatty amide
N-acyl-amine
Amino acid or derivatives
Amino acid
Carboxamide group
Secondary carboxylic acid amide
Carboxylic acid
Dialkylthioether
Monocarboxylic acid or derivatives
Slifenyl compound
Thioether
Amine
Organic oxygen compound
Primary aliphatic amine
Organic nitrogen compound
Hydrocarbon derivative
Carbonyl group
Organic oxide
Organopnictogen compound
Primary amine
Organonitrogen compound
Organooxygen compound
Organoslifur compound
Aliphatic acyclic compound
| Molecliar Framework |
Aliphatic acyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-2.98Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility3.08 mg/mLALOGPS
logP-2.3ALOGPS
logP-3ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)3.88ChemAxon
pKa (Strongest Basic)10.21ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area118.44 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity72.2 m3·mol-1ChemAxon
Polarizability30.74 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28978
| Metagene Link |
HMDB28978
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: PF-06840003
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Li XM, Trinh KY, Hew CL: Expression and characterization of an active and thermally more stable recombinant antifreeze polypeptide from ocean pout, Macrozoarces americanus, in Escherichia coli: improved expression by the modification of the secondary structure of the mRNA. Protein Eng. 1991 Dec;4(8):995-1002. [PubMed:1817264 ]
- McFadden RG, Vickers KE: Bradykinin augments the in vitro migration of nonsensitized lymphocytes. Clin Invest Med. 1989 Aug;12(4):247-53. [PubMed:2562502 ]
- Boric MP, Figueroa XF, Albertini R, Roblero JS: Croxattos fifty-year pursuit: from pepsanurin to the discovery of a new kininogen-derived peptide (PU-D1). Biol Res. 1998;31(3):117-29. [PubMed:9830498 ]
|
PMID: 8692282