| Common Name |
Hydroxyprolyl-Methionine
| Description |
Hydroxyprolyl-Methionine is a dipeptide composed of hydroxyproline and methionine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Structure for HMDB28869 (Hydroxyprolyl-Methionine)
| Synonyms |
| Value |
Source |
Hydroxyproline methionine dipeptideHMDB
HP-m DipeptideHMDB
HPM DipeptideHMDB
hpro-MetHMDB
Hydroxyproline-methionine dipeptideHMDB
HydroxyprolylmethionineHMDB
L-Hydroxyprolyl-L-methionineHMDB
| Chemical Formlia |
C10H18N2O4S
| Average Molecliar Weight |
262.326
| Monoisotopic Molecliar Weight |
262.098727764
| IUPAC Name |
2-[(4-hydroxypyrrolidin-2-yl)formamido]-4-(methylslifanyl)butanoic acid
| Traditional Name |
2-[(4-hydroxypyrrolidin-2-yl)formamido]-4-(methylslifanyl)butanoic acid
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(NC(=O)C1CC(O)CN1)C(O)=O
| InChI Identifier |
InChI=1S/C10H18N2O4S/c1-17-3-2-7(10(15)16)12-9(14)8-4-6(13)5-11-8/h6-8,11,13H,2-5H2,1H3,(H,12,14)(H,15,16)
| InChI Key |
XTTZAXBOUXWPAU-UHFFFAOYSA-N
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid moleclies (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Peptides
| Alternative Parents |
N-acyl-alpha amino acids
Thia fatty acids
Heterocyclic fatty acids
Hydroxy fatty acids
Pyrrolidines
1,2-aminoalcohols
Secondary alcohols
Amino acids
Slifenyl compounds
Propargyl-type 1,3-dipolar organic compounds
Azacyclic compounds
Carboximidic acids
Monocarboxylic acids and derivatives
Dialkylthioethers
Dialkylamines
Carboxylic acids
Organopnictogen compounds
Hydrocarbon derivatives
Organic oxides
Carbonyl compounds
| Substituents |
Alpha peptide
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid or derivatives
Heterocyclic fatty acid
Hydroxy fatty acid
Thia fatty acid
Fatty acyl
Fatty acid
Pyrrolidine
1,2-aminoalcohol
Amino acid or derivatives
Amino acid
Secondary alcohol
Carboximidic acid
Carboximidic acid derivative
Carboxylic acid
Secondary aliphatic amine
Monocarboxylic acid or derivatives
Azacycle
Organoheterocyclic compound
Dialkylthioether
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Secondary amine
Slifenyl compound
Thioether
Amine
Organopnictogen compound
Carbonyl group
Organonitrogen compound
Organooxygen compound
Organoslifur compound
Organic nitrogen compound
Alcohol
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Aliphatic heteromonocyclic compound
| Molecliar Framework |
Aliphatic heteromonocyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.6Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility5.26 mg/mLALOGPS
logP-1.9ALOGPS
logP-3.6ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)3.63ChemAxon
pKa (Strongest Basic)9.12ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area98.66 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity63.77 m3·mol-1ChemAxon
Polarizability26.39 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28869
| Metagene Link |
HMDB28869
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: SDMA
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
Not Available |
PMID: 10602316