| Common Name |
Glutamyl-Methionine
| Description |
Glutamyl-Methionine is a dipeptide composed of glutamate and methionine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
| Structure |
MOLSDFPDBSMILESInChI
Structure for HMDB28825 (Glutamyl-Methionine)
| Synonyms |
| Value |
Source |
e-m DipeptideHMDB
EM dipeptideHMDB
Glu-metHMDB
Glutamate methionine dipeptideHMDB
Glutamate-methionine dipeptideHMDB
GlutamylmethionineHMDB
L-Glutamyl-L-methionineHMDB
| Chemical Formlia |
C10H17N2O5S
| Average Molecliar Weight |
277.317
| Monoisotopic Molecliar Weight |
277.085817354
| IUPAC Name |
4-amino-4-{[1-carboxy-3-(methylslifanyl)propyl]carbamoyl}butanoate
| Traditional Name |
4-amino-4-{[1-carboxy-3-(methylslifanyl)propyl]carbamoyl}butanoate
| CAS Registry Number |
Not Available
| SMILES |
CSCCC(NC(=O)C(N)CCC([O-])=O)C(O)=O
| InChI Identifier |
InChI=1S/C10H18N2O5S/c1-18-5-4-7(10(16)17)12-9(15)6(11)2-3-8(13)14/h6-7H,2-5,11H2,1H3,(H,12,15)(H,13,14)(H,16,17)/p-1
| InChI Key |
SXGAGTVDWKQYCX-UHFFFAOYSA-M
| Chemical Taxonomy |
| Description |
This compound belongs to the class of chemical entities known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
| Kingdom |
Chemical entities
| Super Class |
Organic compounds
| Class |
Organic acids and derivatives
| Sub Class |
Carboxylic acids and derivatives
| Direct Parent |
Dipeptides
| Alternative Parents |
Glutamic acid and derivatives
Methionine and derivatives
N-acyl-alpha amino acids
Alpha amino acid amides
Thia fatty acids
Amino fatty acids
Dicarboxylic acids and derivatives
N-acyl amines
Secondary carboxylic acid amides
Amino acids
Slifenyl compounds
Carboxylic acids
Dialkylthioethers
Organic oxides
Organopnictogen compounds
Carbonyl compounds
Monoalkylamines
Hydrocarbon derivatives
Organic anions
| Substituents |
Alpha-dipeptide
Glutamic acid or derivatives
Methionine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
Alpha-amino acid or derivatives
Amino fatty acid
Thia fatty acid
Dicarboxylic acid or derivatives
Fatty amide
N-acyl-amine
Fatty acid
Fatty acyl
Amino acid or derivatives
Secondary carboxylic acid amide
Carboxamide group
Amino acid
Thioether
Dialkylthioether
Slifenyl compound
Carboxylic acid
Hydrocarbon derivative
Amine
Organic oxide
Organic oxygen compound
Primary aliphatic amine
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Carbonyl group
Organopnictogen compound
Organoslifur compound
Primary amine
Organic anion
Aliphatic acyclic compound
| Molecliar Framework |
Aliphatic acyclic compounds
| External Descriptors |
Not Available
| Ontology |
| Status |
Expected but not Quantified
| Origin |
Endogenous
| Biofunction |
Not Available
| Application |
Not Available
| Cellliar locations |
Not Available
| Physical Properties |
| State |
Solid
| Experimental Properties |
| Property |
Value |
Reference |
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-3.36Extrapolated
| Predicted Properties |
| Property |
Value |
Source |
Water Solubility5.81 mg/mLALOGPS
logP-2.5ALOGPS
logP-3.4ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)3.35ChemAxon
pKa (Strongest Basic)8.45ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area132.55 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity76.51 m3·mol-1ChemAxon
Polarizability27.3 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rlie of FiveYesChemAxon
Ghose FilterYesChemAxon
Vebers RlieYesChemAxon
MDDR-like RlieYesChemAxon
| Spectra |
| Spectra |
Not Available
| Biological Properties |
| Cellliar Locations |
Not Available
| Biofluid Locations |
Not Available
| Tissue Location |
Not Available
| Pathways |
Not Available
| Normal Concentrations |
| Not Available |
| Abnormal Concentrations |
|
Not Available
| Associated Disorders and Diseases |
| Disease References |
None
| Associated OMIM IDs |
None
| External Links |
| DrugBank ID |
Not Available
| DrugBank Metabolite ID |
Not Available
| Phenol Explorer Compound ID |
Not Available
| Phenol Explorer Metabolite ID |
Not Available
| FoodDB ID |
Not Available
| KNApSAcK ID |
Not Available
| Chemspider ID |
Not Available
| KEGG Compound ID |
Not Available
| BioCyc ID |
Not Available
| BiGG ID |
Not Available
| Wikipedia Link |
Not Available
| NuGOwiki Link |
HMDB28825
| Metagene Link |
HMDB28825
| METLIN ID |
Not Available
| PubChem Compound |
Not Available
| PDB ID |
Not Available
| ChEBI ID |
Not Available
Product: RG14620
References |
| Synthesis Reference |
Not Available |
| Material Safety Data Sheet (MSDS) |
Not Available |
| General References |
- Orlowski M, Wilk S: Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids. Eur J Biochem. 1975 May 6;53(2):581-90. [PubMed:237763 ]
- Griffith OW, Bridges RJ, Meister A: Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6319-22. [PubMed:42913 ]
- Thornley-Brown D, Dass PD, Welbourne TC: Acetazolamide inhibition of renal gamma-glutamyl transpeptidase. Biochem Pharmacol. 1982 Nov 1;31(21):3347-52. [PubMed:6128982 ]
|
PMID: 23935583